Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction Final results of the randomized national multicentre trial—PRAGUE-2

Primary percutaneous coronary intervention (PCI) is shown to be the most effective reperfusion strategy in acute myocardial infarction. The aim of this multicentre national randomized mortality trial was to test whether the nationwide change in treatment guidelines (transportation of all patients to PCI centres) was warranted.

The PRAGUE-2 study randomized 850 patients with acute ST elevation myocardial infarction presenting within 3 h after the onset of symptoms, the mortality of the TL group reached 15.3% compared to 6% in the PCI group (P3 h after symptom onset. For patients presenting within