Skeletal Involution by Age-associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids
Bone Health and Osteoporosis Foundation · University of Arkansas for Medical Sciences · +1 more institution
Abstract
Both aging and loss of sex steroids have adverse effects on skeletal homeostasis, but whether and how they may influence each others negative impact on bone remains unknown. We report herein that both female and male C57BL/6 mice progressively lost strength (as determined by load-to-failure measurements) and bone mineral density in the spine and femur between the ages of 4 and 31 months. These changes were temporally associated with decreased rate of remodeling as evidenced by decreased osteoblast and osteoclast numbers and decreased bone formation rate; as well as increased osteoblast and osteocyte apoptosis, increased reactive oxygen species levels, and decreased glutathione reductase activity and a…
Citation impact
- FWCI
- 20.52
- Percentile
- 100%
- References
- 89
Authors
13Topics & keywords
- Endocrinology
- Oxidative stress
- Internal medicine
- Osteoblast
- Osteocyte
- Reactive oxygen species
- Homeostasis
- Osteoclast