reviewGutAug 24, 2005BRONZE OA

PROSTAGLANDINS AND CANCER

DWDiandian Wang

Vanderbilt University Medical Center

PubMed
Indexed incrossrefpubmed

Abstract

Chemoprevention has been considered as a possible approach for cancer prevention. A significant effort has been made in the development of novel drugs for both cancer prevention and treatment over the past decade. Recent epidemiological studies and clinical trials indicate that long term use of aspirin and similar agents, also called non-steroidal anti-inflammatory drugs (NSAIDs), can decrease the incidence of certain malignancies, including colorectal, oesophageal, breast, lung, and bladder cancers. The best known targets of NSAIDs are cyclooxygenase (COX) enzymes, which convert arachidonic acid to prostaglandins (PGs) and thromboxane. COX-2 derived prostaglandin E(2)(PGE(2)) can promote tumour growth by…

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891
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FWCI
34.34
Percentile
100%
References
137
Citations per year

Authors

1

Topics & keywords

Topics
Keywords
  • Medicine
  • Angiogenesis
  • Aspirin
  • Cancer
  • Cyclooxygenase
  • Colorectal cancer
  • Pharmacology
  • Metastasis
UN Sustainable Development Goals
  • Good health and well-being
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