Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer’s disease
University Memory and Aging Center · University of California, San Francisco · +3 more institutions
Abstract
Resting-state or intrinsic connectivity network functional magnetic resonance imaging provides a new tool for mapping large-scale neural network function and dysfunction. Recently, we showed that behavioural variant frontotemporal dementia and Alzheimer's disease cause atrophy within two major networks, an anterior 'Salience Network' (atrophied in behavioural variant frontotemporal dementia) and a posterior 'Default Mode Network' (atrophied in Alzheimer's disease). These networks exhibit an anti-correlated relationship with each other in the healthy brain. The two diseases also feature divergent symptom-deficit profiles, with behavioural variant frontotemporal dementia undermining social-emotional function and…
Citation impact
- FWCI
- 33.88
- Percentile
- 100%
- References
- 106
Authors
10- JZJuan ZhouCorresponding
University Memory and Aging Center, University of California, San Francisco
- MDMichael D. Greicius
Stanford University
- EDEfstathios D. Gennatas
University Memory and Aging Center, University of California, San Francisco
- MEMatthew E. Growdon
University Memory and Aging Center, University of California, San Francisco
- JYJung Yun Jang
University of California, San Francisco, University Memory and Aging Center
Topics & keywords
- Frontotemporal dementia
- Dementia
- Alzheimer's disease
- Neuroscience
- Disease
- Psychology
- Medicine
- Pathology
Funding
- AAAlzheimer's AssociationAwards: K23-AG031861, AG027859, NIRG-07-59422
- LLLarry L. Hillblom FoundationAward: 2005/2T
- NINational Institute on AgingAwards: P01 AG19724, AG19724, P50 AG1657303-75271, K23-AG031861, K08 AG027086, R01-AG027859, P50 AG1657303
- NINational Institute of Neurological Disorders and StrokeAward: K23NS048302