articleApplied Physiology Nutrition and MetabolismOct 1, 2008Closed access

A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care

MMMarina MourtzakisCMCarla M. PradoJLJessica LieffersTRTony ReimanLJLinda J. McCargar

University of Alberta

PubMed
Indexed incrossrefpubmed

Abstract

Human body composition is important in numerous cancer research domains. Our objective was to evaluate clinically accessible methods to achieve practical and precise measures of body composition in cancer patients. Dual-energy X-ray absorptiometry (DXA)-based analysis of fat and fat-free mass was performed in 50 cancer patients and compared with bioelectrical impedance analysis (BIA) and with regional computed tomography (CT) images available in the patients' medical records. BIA overestimated or underestimated fat-free mass substantially compared with DXA as the method of reference (up to 9.3 kg difference). Significant changes in fat-free mass over time detected with DXA in a subset of 21 patients (+2.2 +/-…

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Topics & keywords

Topics
Keywords
  • Bioelectrical impedance analysis
  • Medicine
  • Adipose tissue
  • Fat free mass
  • Nuclear medicine
  • Radiology
  • Computed tomography
  • Cancer
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