Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK

While NF-kappaB is considered to play key roles in the development and progression of many cancers, the mechanisms whereby this transcription factor is activated in cancer are poorly understood. A key oncoprotein in a variety of cancers is the serine-threonine kinase Akt, which can be activated by mutations in PI3K, by loss of expression/activity of PTEN, or through signaling induced by growth factors and their receptors. A key effector of Akt-induced signaling is the regulatory protein mTOR (mammalian target of rapamycin). We show here that mTOR downstream from Akt controls NF-kappaB activity in PTEN-null/inactive prostate cancer cells via interaction with and stimulation of IKK. The mTOR-associated protein…

• UD
  U.S. Department of Defense
• SW
  Samuel Waxman Cancer Research Foundation
• NI
  National Institutes of Health

  Awards: AI35098, CA75080, T32 AI007273, CA73756