Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis
Brigham and Women's Hospital · Harvard University · +3 more institutions
Abstract
Multiple sclerosis (MS) is considered to be an autoimmune disease of the central nervous system (CNS) that in many patients first presents clinically as optic neuritis. The relationship of optic neuritis to MS is not well understood. We have generated novel T cell receptor (TCR) transgenic mice specific for myelin oligodendrocyte glycoprotein (MOG). MOG-specific transgenic T cells are not deleted nor tolerized and are functionally competent. A large proportion (>30%) of MOG-specific TCR transgenic mice spontaneously develop isolated optic neuritis without any clinical nor histological evidence of experimental autoimmune encephalomyelitis (EAE). Optic neuritis without EAE could also be induced in these mice by…
Citation impact
- FWCI
- 13.06
- Percentile
- 100%
- References
- 38
Authors
6- EBEstelle BettelliCorresponding
Brigham and Women's Hospital, Harvard University
- MPMaria Pagany
Max Planck Institute of Neurobiology
- HLHoward L. Weiner
Brigham and Women's Hospital, Harvard University
- CLChristopher Linington
University of Aberdeen, Max Planck Institute of Neurobiology
- RARaymond A. Sobel
Stanford University
Topics & keywords
- Myelin oligodendrocyte glycoprotein
- Optic neuritis
- Experimental autoimmune encephalomyelitis
- Medicine
- Multiple sclerosis
- Immunology
- Pathology
- Good health and well-being