Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
École Nationale Supérieure de Chimie de Montpellier · BC Cancer Agency · +4 more institutions
Abstract
Carbonic anhydrase IX (CAIX) is a hypoxia and HIF-1-inducible protein that regulates intra- and extracellular pH under hypoxic conditions and promotes tumor cell survival and invasion in hypoxic microenvironments. Interrogation of 3,630 human breast cancers provided definitive evidence of CAIX as an independent poor prognostic biomarker for distant metastases and survival. shRNA-mediated depletion of CAIX expression in 4T1 mouse metastatic breast cancer cells capable of inducing CAIX in hypoxia resulted in regression of orthotopic mammary tumors and inhibition of spontaneous lung metastasis formation. Stable depletion of CAIX in MDA-MB-231 human breast cancer xenografts also resulted in attenuation of primary…
Citation impact
- FWCI
- 19.95
- Percentile
- 100%
- References
- 51
Authors
24- YLYuanmei LouCorresponding
École Nationale Supérieure de Chimie de Montpellier, BC Cancer Agency, Centre National de la Recherche Scientifique, Université de Montpellier, Toronto General Hospital, Institut des Biomolécules Max Mousseron
- PCPaul C. McDonald
École Nationale Supérieure de Chimie de Montpellier, BC Cancer Agency, Centre National de la Recherche Scientifique, Université de Montpellier, Toronto General Hospital, Institut des Biomolécules Max Mousseron
- AOArusha Oloumi
École Nationale Supérieure de Chimie de Montpellier, BC Cancer Agency, Centre National de la Recherche Scientifique, Université de Montpellier, Toronto General Hospital, Institut des Biomolécules Max Mousseron
- SCStephen Chia
École Nationale Supérieure de Chimie de Montpellier, BC Cancer Agency, Centre National de la Recherche Scientifique, Université de Montpellier, Toronto General Hospital, Institut des Biomolécules Max Mousseron
- COChristina Ostlund
École Nationale Supérieure de Chimie de Montpellier, BC Cancer Agency, Centre National de la Recherche Scientifique, Université de Montpellier, Toronto General Hospital, Institut des Biomolécules Max Mousseron
Topics & keywords
- Metastasis
- Cancer research
- Breast cancer
- Tumor hypoxia
- Metastatic breast cancer
- Mammary tumor
- Primary tumor
- Cancer
- Good health and well-being