Evidence for Cardiomyocyte Renewal in Humans
Université Claude Bernard Lyon 1 · Lawrence Livermore National Laboratory · +4 more institutions
Abstract
It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this…
Citation impact
- FWCI
- 111.19
- Percentile
- 100%
- References
- 29
Authors
12- OBOlaf BergmannCorresponding
Université Claude Bernard Lyon 1, Lawrence Livermore National Laboratory, Centre National de la Recherche Scientifique, Lund University, Karolinska Institutet, Institut Camille Jordan
- RDRatan D. BhardwajCorresponding
Université Claude Bernard Lyon 1, Lawrence Livermore National Laboratory, Centre National de la Recherche Scientifique, Lund University, Karolinska Institutet, Institut Camille Jordan
- SBSamuel Bernard
Université Claude Bernard Lyon 1, Lawrence Livermore National Laboratory, Centre National de la Recherche Scientifique, Lund University, Karolinska Institutet, Institut Camille Jordan
- SZSofia Zdunek
Université Claude Bernard Lyon 1, Lawrence Livermore National Laboratory, Centre National de la Recherche Scientifique, Lund University, Karolinska Institutet, Institut Camille Jordan
- FBFanie Barnabé‐Heider
Université Claude Bernard Lyon 1, Lawrence Livermore National Laboratory, Centre National de la Recherche Scientifique, Lund University, Karolinska Institutet, Institut Camille Jordan
Topics & keywords
- Myocyte
- Life span
- Human heart
- Cell biology
- Biology
- Cardiac muscle
- Internal medicine
- Medicine