Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction
Johns Hopkins University · Johns Hopkins Hospital · +1 more institution
Abstract
Although clinical trials of autologous whole bone marrow for cardiac repair demonstrate promising results, many practical and mechanistic issues regarding this therapy remain highly controversial. Here, we report the results of a randomized study of bone-marrow-derived mesenchymal stem cells, administered to pigs, which offer several new insights regarding cellular cardiomyoplasty. First, cells were safely injected by using a percutaneous-injection catheter 3 d after myocardial infarction. Second, cellular transplantation resulted in long-term engraftment, profound reduction in scar formation, and near-normalization of cardiac function. Third, transplanted cells were pre-prepared from an allogeneic donor and…
Citation impact
- FWCI
- 55.81
- Percentile
- 100%
- References
- 51
Authors
15- LCLuciano C. AmadoCorresponding
Johns Hopkins University, Johns Hopkins Hospital, Osiris Therapeutics (United States)
- ASAnastasios Saliaris
Johns Hopkins University, Johns Hopkins Hospital, Osiris Therapeutics (United States)
- KHKarl H. Schuleri
Johns Hopkins University, Johns Hopkins Hospital, Osiris Therapeutics (United States)
- MSMarcus St. John
Johns Hopkins University, Johns Hopkins Hospital, Osiris Therapeutics (United States)
- JXJin-Sheng Xie
Johns Hopkins University, Johns Hopkins Hospital, Osiris Therapeutics (United States)
Topics & keywords
- Mesenchymal stem cell
- Medicine
- Stem cell
- Myocardial infarction
- Transplantation
- Cardiac function curve
- Cell therapy
- Stem-cell therapy
- Good health and well-being