The Role of Interneuron Networks in Driving Human Motor Cortical Plasticity
University College London · National Hospital for Neurology and Neurosurgery · +1 more institution
Abstract
The after-effects of repetitive transcranial magnetic stimulation (rTMS) are highly variable between individuals. Because different populations of cortical neurons are stimulated more easily or are more excitable in different people at different times, the variability may not be due to differences between individuals in the plasticity of cortical synapses, but may instead be due to individual differences in the recruitment of cortical neurons. In this study, we examined the effects of rTMS in 56 healthy volunteers. The responses to excitatory and inhibitory theta burst stimulation (TBS) protocols were highly variable between individuals. Surprisingly, the TBS effect was highly correlated with the latency of…
Citation impact
- FWCI
- 33.31
- Percentile
- 100%
- References
- 72
Authors
5- MHMasashi HamadaCorresponding
University College London, National Hospital for Neurology and Neurosurgery
- NMNagako Murase
University College London, National Hospital for Neurology and Neurosurgery
- AHA. Hasan
University College London, National Hospital for Neurology and Neurosurgery, University of Göttingen
- MBMichelle Balaratnam
University College London, National Hospital for Neurology and Neurosurgery
- JCJohn C. Rothwell
University College London, National Hospital for Neurology and Neurosurgery
Topics & keywords
- Transcranial magnetic stimulation
- Neuroscience
- Inhibitory postsynaptic potential
- Motor cortex
- Excitatory postsynaptic potential
- Central sulcus
- Interneuron
- Psychology
- Good health and well-being