Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
The Wistar Institute · Cancer Research Institute · +4 more institutions
Abstract
A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell…
Citation impact
- FWCI
- 28.39
- Percentile
- 100%
- References
- 39
Authors
15- JTJohn T. ChangCorresponding
The Wistar Institute, Cancer Research Institute, University of California, San Francisco, Peter MacCallum Cancer Centre, University of Pennsylvania
- VPV. Palanivel
The Wistar Institute, Cancer Research Institute, University of California, San Francisco, Peter MacCallum Cancer Centre, University of Pennsylvania
- IKIchiko Kinjyo
The Wistar Institute, Cancer Research Institute, University of California, San Francisco, Peter MacCallum Cancer Centre, University of Pennsylvania
- FSFelix Schambach
The Wistar Institute, Cancer Research Institute, University of California, San Francisco, Peter MacCallum Cancer Centre, University of Pennsylvania
- AMAndrew M. Intlekofer
The Wistar Institute, Cancer Research Institute, University of California, San Francisco, Peter MacCallum Cancer Centre, University of Pennsylvania
Topics & keywords
- Cell division
- Biology
- Effector
- Asymmetric cell division
- Immune system
- Lymphocyte
- Acquired immune system
- Cell biology