A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients

Tumor-associated macrophages (TAMs) are classified into two major phenotypes, M1 and M2. M1 TAMs suppress cancer progression, while M2 TAMs promote it. However, little is known regarding the role of TAMs in the development of ovarian cancer. Here, we investigated the relationship between TAM distribution patterns (density, microlocalization, and differentiation) and ovarian cancer histotypes, and we explored whether altered TAM distribution patterns influence long-term outcomes in ovarian cancer patients.

A total of 112 ovarian cancer patients were enrolled in this study, and the subjects were divided into two groups according to their survival (