MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene
University of Louisville · Fudan University · +7 more institutions
Abstract
MicroRNA-155 (miR-155) is overexpressed in many human cancers; however, the mechanisms by which miR-155 functions as a putative oncomiR are largely unknown. Here, we report that the tumor suppressor gene suppressor of cytokine signaling 1 (socs1) is an evolutionarily conserved target of miR-155 in breast cancer cells. We found that mir-155 expression is inversely correlated with socs1 expression in breast cancer cell lines as well as in a subset of primary breast tumors. We also identified a 24A-->G mutation in the miR-155 binding site of the SOCS1 3' untranslated region in a breast tumor that reduced miR-155 repression, implicating a mechanism for miRNA targets to avoid repression. Ectopic expression of…
Citation impact
- FWCI
- 22.96
- Percentile
- 100%
- References
- 38
Authors
8- SJShuai Jiang
University of Louisville, Fudan University, Shanghai Institutes for Biological Sciences, Center for Excellence in Molecular Cell Science, Zhongshan Hospital, Lanzhou University
- HZHong-Wei Zhang
University of Louisville, Sun Yat-sen University, Fudan University, Shanghai Institutes for Biological Sciences, Center for Excellence in Molecular Cell Science, Zhongshan Hospital, The First Affiliated Hospital, Sun Yat-sen University, Lanzhou University, Columbia University
- MLMing-Hua Lu
University of Louisville, Fudan University, Shanghai Institutes for Biological Sciences, Center for Excellence in Molecular Cell Science, Zhongshan Hospital, Lanzhou University, Columbia University
- XHXiao-Hong He
University of Louisville, Fudan University, Shanghai Institutes for Biological Sciences, Center for Excellence in Molecular Cell Science, Zhongshan Hospital, Lanzhou University, Columbia University
- YLYong Li
University of Louisville, Sun Yat-sen University, Fudan University, Shanghai Institutes for Biological Sciences, Center for Excellence in Molecular Cell Science, Zhongshan Hospital, The First Affiliated Hospital, Sun Yat-sen University, Lanzhou University, Columbia University
Topics & keywords
- Oncomir
- Suppressor of cytokine signaling 1
- microRNA
- Cancer research
- miR-155
- Biology
- Gene silencing
- Breast cancer
- Good health and well-being
Funding
- CWCase Western Reserve University
- NNNational Natural Science Foundation of ChinaAward: 30970621
- CAChinese Academy of SciencesAward: KSCX2-YW-R
- SIShanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- SAScience and Technology Commission of Shanghai Municipality
- DFDirectorate for Biological Sciences