Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines
North Carolina State University · SIB Swiss Institute of Bioinformatics · +8 more institutions
Abstract
The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic variation on molecular and organismal phenotypes. We used an integrated genotyping strategy to identify 4,853,802 single nucleotide polymorphisms (SNPs) and 1,296,080 non-SNP variants. Our molecular population genomic analyses show higher deletion than insertion mutation rates and stronger purifying selection on deletions. Weaker selection on insertions than deletions is consistent with our observed distribution of genome size determined by flow cytometry, which is skewed toward larger genomes. Insertion/deletion and…
Citation impact
- FWCI
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- Percentile
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- References
- 100
Authors
51- WHWen HuangCorresponding
North Carolina State University
- AMAndreas Massouras
SIB Swiss Institute of Bioinformatics, École Polytechnique Fédérale de Lausanne
- YIYutaka Inoue
Osaka University of Arts, The University of Osaka
- JAJason A. Peiffer
North Carolina State University
- MRMiquel Ràmia
Universitat Autònoma de Barcelona
Topics & keywords
- Biology
- Genetics
- Genome
- Genetic variation
- Single-nucleotide polymorphism
- Reference genome
- Drosophila melanogaster
- Population
Funding
- NSNational Science FoundationAward: 1062178
- UDU.S. Department of Justice
- TATexas AgriLife Research
- DFDeutsche Forschungsgemeinschaft
- ÉPÉcole Polytechnique Fédérale de Lausanne
- SNSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungAwards: 59469, CRSI33_127485
- NINational Institutes of HealthAwards: AA016560, GM45146, GM076083, R01 GM076083, R01 AA016560, U54 HG003273, NHGRI U54 HG003273, R01 GM45146
- NHNational Human Genome Research InstituteAwards: U54 HG003273, HG003273