Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review
Erasmus University Rotterdam · Erasmus MC · +4 more institutions
Abstract
Frontotemporal dementia (FTD) is the second most common young-onset dementia and is clinically characterised by progressive behavioural change, executive dysfunction and language difficulties. Three clinical syndromes, behavioural variant FTD, semantic dementia and progressive non-fluent aphasia, form part of a clinicopathological spectrum named frontotemporal lobar degeneration (FTLD). The classical neuropsychological phenotype of FTD has been enriched by tests exploring Theory of Mind, social cognition and emotional processing. Imaging studies have detailed the patterns of atrophy associated with different clinical and pathological subtypes. These patterns offer some diagnostic utility, while measures of…
Citation impact
- FWCI
- 28.63
- Percentile
- 100%
- References
- 235
Authors
5- HSHarro SeelaarCorresponding
Erasmus University Rotterdam, Erasmus MC
- JDJonathan D. Rohrer
University College London, UK Dementia Research Institute, National Hospital for Neurology and Neurosurgery
- YAYolande A.L. Pijnenburg
Amsterdam UMC Location VUmc
- NCNick C. Fox
University College London, National Hospital for Neurology and Neurosurgery, UK Dementia Research Institute
- JCJohn C. van Swieten
University College London, Erasmus University Rotterdam, Erasmus MC, National Hospital for Neurology and Neurosurgery
Topics & keywords
- Frontotemporal dementia
- Genetic heterogeneity
- Pathological
- Dementia
- Neuroscience
- Medicine
- Psychology
- Genetics
- Reduced inequalities