Prevalence, Predictors, and Outcomes of Premature Discontinuation of Thienopyridine Therapy After Drug-Eluting Stent Placement
University of Colorado Hospital · Barnes-Jewish Hospital · +6 more institutions
Abstract
BACKGROUND: Although drug-eluting stents (DES) significantly reduce restenosis, they require 3 to 6 months of thienopyridine therapy to prevent stent thrombosis. The rate and consequences of prematurely discontinuing thienopyridine therapy after DES placement for acute myocardial infarction (MI) are unknown. METHODS AND RESULTS: We used prospectively collected data from a 19-center study of MI patients to examine the prevalence and predictors of thienopyridine discontinuation 30 days after DES treatment. We then compared the mortality and cardiac hospitalization rates for the next 11 months between those who stopped and those who continued thienopyridine therapy. Among 500 DES-treated MI patients who were…
Citation impact
- FWCI
- 98.63
- Percentile
- 100%
- References
- 40
Authors
12- JAJohn A. SpertusCorresponding
University of Colorado Hospital, Barnes-Jewish Hospital, Henry Ford Health System, Duke University, Yale University, University of Colorado Health, Denver VA Medical Center, University of Colorado Denver
- RKRichard Kettelkamp
University of Colorado Hospital, Barnes-Jewish Hospital, Henry Ford Health System, Duke University, Yale University, University of Colorado Health, Denver VA Medical Center, University of Colorado Denver
- CVClifton Vance
University of Colorado Hospital, Barnes-Jewish Hospital, Henry Ford Health System, Duke University, Yale University, University of Colorado Health, Denver VA Medical Center, University of Colorado Denver
- CDCarole Decker
University of Colorado Hospital, Barnes-Jewish Hospital, Henry Ford Health System, Duke University, Yale University, University of Colorado Health, Denver VA Medical Center, University of Colorado Denver
- PGPhilip G. Jones
University of Colorado Hospital, Barnes-Jewish Hospital, Henry Ford Health System, Duke University, Yale University, University of Colorado Health, Denver VA Medical Center, University of Colorado Denver
Topics & keywords
- Medicine
- Thienopyridine
- Discontinuation
- Drug
- Internal medicine
- Drug-eluting stent
- Cardiology
- Intensive care medicine
- Good health and well-being