The composition of the gut microbiota shapes the colon mucus barrier
University of Gothenburg · Norwegian University of Life Sciences · +2 more institutions
Abstract
Two C57BL/6 mice colonies maintained in two rooms of the same specific pathogen-free (SPF) facility were found to have different gut microbiota and a mucus phenotype that was specific for each colony. The thickness and growth of the colon mucus were similar in the two colonies. However, one colony had mucus that was impenetrable to bacteria or beads the size of bacteria-which is comparable to what we observed in free-living wild mice-whereas the other colony had an inner mucus layer penetrable to bacteria and beads. The different properties of the mucus depended on the microbiota, as they were transmissible by transfer of caecal microbiota to germ-free mice. Mice with an impenetrable mucus layer had increased…
Citation impact
- FWCI
- 20.51
- Percentile
- 100%
- References
- 73
Authors
10Topics & keywords
- Mucus
- Gut flora
- Composition (language)
- Biology
- Microbiology
- Mucin
- Immunology
- Biochemistry
Funding
- SCSwedish Cancer FoundationAward: U01AI095473
- SFStiftelsen för Strategisk Forskning
- KOKnut och Alice Wallenbergs StiftelseAward: U01AI095473
- VVetenskapsrådetAwards: U01AI095473, 22220‐01‐5, 21027
- GUGöteborgs Universitet
- NINational Institutes of HealthAward: U01AI095473
- SASahlgrenska AkademinAward: U01AI095473
- NINational Institute of Allergy and Infectious DiseasesAwards: 9006862, U01AI095776, U01AI095776‐03:9006862, U01AI095473