Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers
Radboud University Nijmegen · Radboud University Medical Center · +29 more institutions
Abstract
Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies, pathology reporting and the patient's perspective on multiple aspects, including diet post gastrectomy. The updated guidelines include revised CDH1 testing criteria (taking into account first-degree and second-degree relatives): (1) families with two or more patients with gastric cancer at any age, one confirmed DGC; (2) individuals with DGC before the age of 40 and (3) families with diagnoses of both DGC and LBC (one diagnosis before the age of 50). Additionally, CDH1 testing could be…
Citation impact
- FWCI
- 42.89
- Percentile
- 100%
- References
- 121
Authors
48- RSRachel S. van der Post
Radboud University Nijmegen, Radboud University Medical Center
- IPIngrid P. Vogelaar
Radboud University Nijmegen, Radboud University Medical Center
- FCFátima Carneiro
Universidade do Porto, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- PGParry Guilford
University of Otago
- DGDavid G. Huntsman
BC Cancer Agency
Topics & keywords
- CDH1
- Medicine
- Breast cancer
- Germline mutation
- Cancer
- Genetic testing
- Signet ring cell carcinoma
- Gastrectomy