Exercise Hemodynamics Enhance Diagnosis of Early Heart Failure With Preserved Ejection Fraction

BACKGROUND: When advanced, heart failure with preserved ejection fraction (HFpEF) is readily apparent. However, diagnosis of earlier disease may be challenging because exertional dyspnea is not specific for heart failure, and biomarkers and hemodynamic indicators of volume overload may be absent at rest. METHODS AND RESULTS: Patients with exertional dyspnea and ejection fraction >50% were referred for hemodynamic catheterization. Those with no significant coronary disease, normal brain natriuretic peptide assay, and normal resting hemodynamics (mean pulmonary artery pressure

• MC
  Mayo Clinic

  Award: RR024150
• NI
  National Institutes of Health

  Awards: P01 HL 76611, UL RR024150, RR024150