Phase III Trial of Chemotherapy Plus Radiotherapy Compared With Radiotherapy Alone for Pure and Mixed Anaplastic Oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402
University of Wisconsin–Madison · Thomas Jefferson University · +6 more institutions
Abstract
PURPOSE: Anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA) are treated with surgery and radiotherapy (RT) at diagnosis, but they also respond to procarbazine, lomustine, and vincristine (PCV), raising the possibility that early chemotherapy will improve survival. Furthermore, better outcomes in AO have been associated with 1p and 19q allelic loss. PATIENTS AND METHODS: Patients with AO and AOA were randomly assigned to PCV chemotherapy followed by RT versus postoperative RT alone. The primary end point was overall survival. The status of 1p and 19q alleles was assessed by fluorescence in situ hybridization. RESULTS: Two hundred eighty-nine eligible patients were randomly assigned to…
Citation impact
- FWCI
- 30.76
- Percentile
- 100%
- References
- 25
Authors
12- GCGregory CairncrossCorresponding
University of Wisconsin–Madison, Thomas Jefferson University, University of Toronto, Southwestern Medical Center, Mayo Clinic in Arizona, Wake Forest University, McGill University, The University of Texas Southwestern Medical Center
- BBBrian Berkey
University of Wisconsin–Madison, Thomas Jefferson University, University of Toronto, Southwestern Medical Center, Mayo Clinic in Arizona, Wake Forest University, McGill University, The University of Texas Southwestern Medical Center
- ESEdward Shaw
University of Wisconsin–Madison, Thomas Jefferson University, University of Toronto, Southwestern Medical Center, Mayo Clinic in Arizona, Wake Forest University, McGill University, The University of Texas Southwestern Medical Center
- RBRobert B. Jenkins
University of Wisconsin–Madison, Thomas Jefferson University, University of Toronto, Southwestern Medical Center, Mayo Clinic in Arizona, Wake Forest University, McGill University, The University of Texas Southwestern Medical Center
- BWBernd W. Scheithauer
University of Wisconsin–Madison, Thomas Jefferson University, University of Toronto, Southwestern Medical Center, Mayo Clinic in Arizona, Wake Forest University, McGill University, The University of Texas Southwestern Medical Center
Topics & keywords
- Medicine
- Procarbazine
- Lomustine
- Radiation therapy
- Internal medicine
- Chemotherapy
- Vincristine
- Oligodendroglioma
- Good health and well-being