Selective BRAF Inhibitors Induce Marked T-cell Infiltration into Human Metastatic Melanoma
The University of Sydney · Millennium Institute · +5 more institutions
Abstract
Tumor infiltration by CD4(+) and CD8(+) lymphocytes increased markedly following BRAF inhibitor treatment (both ρ = 0.015). There was a correlation between the degree of tumor infiltration by CD8(+) and Granzyme B-expressing lymphocytes in post-BRAF inhibitor-treated biopsies (r = 0.690 and ρ = 0.013). Increased intratumoral CD8(+) lymphocyte expression was correlated with a reduction in tumor size and an increase in necrosis in posttreatment biopsies (r = -0.793, ρ = 0.011; and r = 0.761, ρ = 0.004, respectively).
The increase in tumor-infiltrating lymphocytes induced by treatment with BRAF inhibitors provides strong support for conducting trials that combine BRAF inhibitors with immunotherapy in the hope of prolonging clinical responses.
Citation impact
- FWCI
- 24.47
- Percentile
- 100%
- References
- 20
Authors
9- JSJames S. WilmottCorresponding
The University of Sydney, Millennium Institute, Royal Prince Alfred Hospital, Royal North Shore Hospital, Westmead Hospital, Westmead Institute, Western Sydney University
- GVGeorgina V. Long
The University of Sydney, Millennium Institute, Royal Prince Alfred Hospital, Royal North Shore Hospital, Westmead Hospital, Westmead Institute, Western Sydney University
- JRJulie R. Howle
The University of Sydney, Millennium Institute, Royal Prince Alfred Hospital, Royal North Shore Hospital, Westmead Hospital, Westmead Institute, Western Sydney University
- LELauren E. Haydu
The University of Sydney, Millennium Institute, Royal Prince Alfred Hospital, Royal North Shore Hospital, Westmead Hospital, Westmead Institute, Western Sydney University
- RSRaghwa Sharma
The University of Sydney, Millennium Institute, Royal Prince Alfred Hospital, Royal North Shore Hospital, Westmead Hospital, Westmead Institute, Western Sydney University
Topics & keywords
- Infiltration (HVAC)
- Metastatic melanoma
- Melanoma
- Medicine
- Cancer research
- Pathology
- Good health and well-being