Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men
Gladstone Institutes · University of California, San Francisco · +21 more institutions
Abstract
Antiretroviral chemoprophylaxis before exposure is a promising approach for the prevention of human immunodeficiency virus (HIV) acquisition.
We randomly assigned 2499 HIV-seronegative men or transgender women who have sex with men to receive a combination of two oral antiretroviral drugs, emtricitabine and tenofovir disoproxil fumarate (FTC-TDF), or placebo once daily. All subjects received HIV testing, risk-reduction counseling, condoms, and management of sexually transmitted infections.
Citation impact
- FWCI
- 141.59
- Percentile
- 100%
- References
- 48
Authors
35- RMRobert M. GrantCorresponding
Gladstone Institutes, University of California, San Francisco, Institute of Virology of the Slovak Academy of Sciences
- JRJavier R. Lama
Asociación Civil Impacta Salud y Educación, EsSALUD
- PLPeter L. Anderson
University of Colorado Denver
- VMVanessa McMahan
Institute of Virology of the Slovak Academy of Sciences
- ALAlbert Liu
University of California, San Francisco, San Francisco Department of Public Health
Topics & keywords
- Medicine
- Emtricitabine
- Chemoprophylaxis
- Placebo
- Pre-exposure prophylaxis
- Adverse effect
- Internal medicine
- Confidence interval
- Good health and well-being