reviewMolecular PsychiatryMay 19, 2009HYBRID OA

Vulnerability genes or plasticity genes?

JBJay BelskyCRCharles R. JonassaintMPMichael PluessMSMichael StantonBHBeverly H. Brummett

Birkbeck, University of London · Duke University · +2 more institutions

PubMed
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Abstract

The classic diathesis-stress framework, which views some individuals as particularly vulnerable to adversity, informs virtually all psychiatric research on behavior-gene-environment (G x E) interaction. An alternative framework of 'differential susceptibility' is proposed, one which regards those most susceptible to adversity because of their genetic make up as simultaneously most likely to benefit from supportive or enriching experiences-or even just the absence of adversity. Recent G x E findings consistent with this perspective and involving monoamine oxidase-A, 5-HTTLPR (5-hydroxytryptamine-linked polymorphic region polymorphism) and dopamine receptor D4 (DRD4) are reviewed for illustrative purposes.…

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Authors

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Topics & keywords

Topics
Keywords
  • Gene
  • Vulnerability (computing)
  • Genetics
  • Computational biology
  • Biology
  • Psychology
  • Computer science
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