New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain
University of California, San Francisco · Keio University · +5 more institutions
Abstract
In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.
Citation impact
- FWCI
- 16.44
- Percentile
- 100%
- References
- 19
Authors
13- KSKazunobu SawamotoCorresponding
University of California, San Francisco, Keio University, Neurological Surgery, Columbia University, Bridgestone (Japan)
- HWHynek Wichterle
University of California, San Francisco, Keio University, Neurological Surgery, Columbia University, Bridgestone (Japan)
- ÓGÓscar González-Pérez
University of California, San Francisco, Keio University, Neurological Surgery, Columbia University, Bridgestone (Japan)
- JAJeremy A. Cholfin
University of California, San Francisco, Keio University, Neurological Surgery, Columbia University, Bridgestone (Japan)
- MYMasayuki Yamada
University of California, San Francisco, Keio University, Central Institute for Experimental Animals, Neurological Surgery, Columbia University, Bridgestone (Japan)
Topics & keywords
- Neuroblast
- Cerebrospinal fluid
- Subventricular zone
- Olfactory bulb
- Lateral ventricles
- Ependymal Cell
- Neuroscience
- Biology