COFACTOR: an accurate comparative algorithm for structure-based protein function annotation

We have developed a new COFACTOR webserver for automated structure-based protein function annotation. Starting from a structural model, given by either experimental determination or computational modeling, COFACTOR first identifies template proteins of similar folds and functional sites by threading the target structure through three representative template libraries that have known protein-ligand binding interactions, Enzyme Commission number or Gene Ontology terms. The biological function insights in these three aspects are then deduced from the functional templates, the confidence of which is evaluated by a scoring function that combines both global and local structural similarities. The algorithm has been…

• NS
  National Science Foundation

  Awards: 0746198, DBI 0746198
• NI
  National Institute of General Medical Sciences

  Awards: GM083107, GM083107, GM084222, GM084222