Regulation of osteoblastogenesis and bone mass by Wnt10b
University of California, Los Angeles · University of Michigan · +2 more institutions
Abstract
Wnts comprise a family of secreted signaling proteins that regulate diverse developmental processes. Activation of Wnt signaling by Wnt10b inhibits differentiation of preadipocytes and blocks adipose tissue development; however, the effect of Wnt10b on other mesenchymal lineages has not been defined. To explore the physiological role of Wnt signaling in bone development, we analyzed FABP4-Wnt10b mice, which express the Wnt10b transgene in marrow. Femurs from FABP4-Wnt10b mice have almost four times as much bone in the distal metaphyses and are mechanically stronger. These mice maintain elevated bone mass at least through 23 months of age. In addition, FABP4-Wnt10b mice are protected from the bone loss…
Citation impact
- FWCI
- 21.86
- Percentile
- 100%
- References
- 44
Authors
7- CNChristina N. BennettCorresponding
University of California, Los Angeles, University of Michigan, University of Arkansas for Medical Sciences
- KLKenneth Longo
University of California, Los Angeles, University of Michigan, University of Arkansas for Medical Sciences
- WSWendy S. Wright
University of California, Los Angeles, University of Michigan, University of Arkansas for Medical Sciences
- LJLarry J. Suva
University of California, Los Angeles, University of Michigan, University of Arkansas for Medical Sciences
- TFTimothy F. Lane
University of California, Los Angeles, University of Michigan, University of Arkansas for Medical Sciences
Topics & keywords
- Adipogenesis
- Wnt signaling pathway
- RUNX2
- Osteocalcin
- Osteoblast
- Cell biology
- Transcription factor
- Biology