Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart
The University of Texas Health Science Center at Houston · Baylor College of Medicine · +1 more institution
Abstract
In animal models of lipotoxicity, accumulation of triglycerides within cardiomyocytes is associated with contractile dysfunction. However, whether intramyocardial lipid deposition is a feature of human heart failure remains to be established. We hypothesized that intramyocardial lipid accumulation is a common feature of non-ischemic heart failure and is associated with changes in gene expression similar to those found in an animal model of lipotoxicity. Intramyocardial lipid staining with oil red O and gene expression analysis was performed on heart tissue from 27 patients (9 female) with non-ischemic heart failure. We determined intramyocardial lipid, gene expression, and contractile function in hearts from 6…
Citation impact
- FWCI
- 14.32
- Percentile
- 100%
- References
- 35
Authors
9- SSSaumya SharmaCorresponding
The University of Texas Health Science Center at Houston
- JAJulia Adrogue
The University of Texas Health Science Center at Houston
- LSLeonard S. Golfman
The University of Texas Health Science Center at Houston
- IPIván P. Uray
The University of Texas Health Science Center at Houston
- JLJohn Lemm
The University of Texas Health Science Center at Houston
Topics & keywords
- Lipotoxicity
- Internal medicine
- Heart failure
- Endocrinology
- Lipid droplet
- Medicine
- Diabetes mellitus
- Cardiology
- Good health and well-being