Intraepithelial CD8 + tumor-infiltrating lymphocytes and a high CD8 + /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
Memorial Sloan Kettering Cancer Center · Cornell University · +5 more institutions
Abstract
In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348, 203-213], the presence of CD3+ tumor-infiltrating lymphocytes (TILs) was found to correlate with improved survival in epithelial ovarian cancer. We performed immunohistochemical analysis for TILs and cancer testis antigens in 117 cases of epithelial ovarian cancer. The interrelationship between subpopulations of TILs and expression of cancer testis antigens was investigated, as well as between TILs and overall survival. The median follow-up of the patients was 31 months. Patients with higher frequencies of intraepithelial CD8+ T cells demonstrated improved survival compared with patients with lower frequencies [median = 55 versus 26 months; hazard…
Citation impact
- FWCI
- 17.81
- Percentile
- 100%
- References
- 36
Authors
18- ESEiichi SatoCorresponding
Memorial Sloan Kettering Cancer Center, Cornell University
- SHSara H. Olson
Memorial Sloan Kettering Cancer Center, Cornell University
- JAJiyoung Ahn
Memorial Sloan Kettering Cancer Center, Cornell University, National Hospital Organization Mito Medical Center
- BNBrian N. Bundy
Memorial Sloan Kettering Cancer Center, Tokyo Medical University, Cornell University
- HNHiroyoshi Nishikawa
Gynecologic Oncology Group, Roswell Park Comprehensive Cancer Center, Memorial Sloan Kettering Cancer Center, Cornell University
Topics & keywords
- Hazard ratio
- CD8
- FOXP3
- Tumor-infiltrating lymphocytes
- Medicine
- Internal medicine
- Oncology
- Antigen
- Good health and well-being