Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity
Okayama University · Okayama University Hospital · +1 more institution
Abstract
There is a rapid global rise in obesity, and the link between obesity and diabetes remains somewhat obscure. We identified an adipocytokine, designated as visceral adipose tissue-derived serpin (vaspin), which is a member of serine protease inhibitor family. Vaspin cDNA was isolated by from visceral white adipose tissues (WATs) of Otsuka Long-Evans Tokushima fatty (OLETF) rat, an animal model of abdominal obesity with type 2 diabetes. Rat, mouse, and human vaspins are made up of 392, 394, and 395 amino acids, respectively; exhibit approximately 40% homology with alpha1-antitrypsin; and are related to serine protease inhibitor family. Vaspin was barely detectable in rats at 6 wk and was highly expressed in…
Citation impact
- FWCI
- 11.31
- Percentile
- 100%
- References
- 41
Authors
19- KHKazuyuki Hida
Okayama University, Okayama University Hospital
- JWJun WadaCorresponding
Northwestern University, Okayama University, Okayama University Hospital
- JEJun Eguchi
Okayama University, Okayama University Hospital
- HZHong Zhang
Okayama University, Okayama University Hospital
- MBMasako Baba
Okayama University, Okayama University Hospital
Topics & keywords
- Internal medicine
- Endocrinology
- Adipose tissue
- Resistin
- Insulin resistance
- Adiponectin
- Insulin
- Type 2 diabetes
- Good health and well-being