Social supports and serotonin transporter gene moderate depression in maltreated children
Yale University · National Center for Post Traumatic Stress Disorder
Abstract
In this study, measures of the quality and availability of social supports were found to moderate risk for depression associated with a history of maltreatment and the presence of the short (s) allele of the serotonin transporter gene promoter polymorphism (5-HTTLPR). The present investigation (i) replicates research in adults showing that 5-HTTLPR variation moderates the development of depression after stress, (ii) extends the finding to children, and (iii) demonstrates the ability of social supports to further moderate risk for depression. Maltreated children with the s/s genotype and no positive supports had the highest depression ratings, scores that were twice as high as the non-maltreated comparison…
Citation impact
- FWCI
- 65.81
- Percentile
- 100%
- References
- 45
Authors
7- JKJoan KaufmanCorresponding
Yale University, National Center for Post Traumatic Stress Disorder
- BYBao‐Zhu Yang
Yale University, National Center for Post Traumatic Stress Disorder
- HDHeather Douglas-Palumberi
Yale University, National Center for Post Traumatic Stress Disorder
- SHShadi Houshyar
Yale University, National Center for Post Traumatic Stress Disorder
- DSDeborah S. Lipschitz
Yale University, National Center for Post Traumatic Stress Disorder
Topics & keywords
- Serotonin transporter
- Depression (economics)
- Psychology
- Genotype
- 5-HTTLPR
- Clinical psychology
- Vulnerability (computing)
- Social stress