CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer
City Of Hope National Medical Center · University of California, Los Angeles · +3 more institutions
Abstract
Radiotherapy is used to treat many types of cancer, but many treated patients relapse with local tumor recurrence. Tumor-infiltrating myeloid cells (TIM), including CD11b (ITGAM)(+)F4/80 (EMR1)+ tumor-associated macrophages (TAM), and CD11b(+)Gr-1 (LY6G)+ myeloid-derived suppressor cells (MDSC), respond to cancer-related stresses and play critical roles in promoting tumor angiogenesis, tissue remodeling, and immunosuppression. In this report, we used a prostate cancer model to investigate the effects of irradiation on TAMs and MDSCs in tumor-bearing animals. Unexpectedly, when primary tumor sites were irradiated, we observed a systemic increase of MDSCs in spleen, lung, lymph nodes, and peripheral blood.…
Citation impact
- FWCI
- 17.81
- Percentile
- 100%
- References
- 52
Authors
9- JXJingying Xu
City Of Hope National Medical Center, University of California, Los Angeles, City of Hope, Beckman Research Institute, Plexxikon (United States)
- JEJemima Escamilla
City Of Hope National Medical Center, University of California, Los Angeles, City of Hope, Beckman Research Institute, Plexxikon (United States)
- SMStephen Mok
City Of Hope National Medical Center, University of California, Los Angeles, City of Hope, Beckman Research Institute, Plexxikon (United States)
- JDJohn David
City Of Hope National Medical Center, University of California, Los Angeles, City of Hope, Beckman Research Institute, Plexxikon (United States)
- SJSaul J. Priceman
City Of Hope National Medical Center, University of California, Los Angeles, City of Hope, Beckman Research Institute, Plexxikon (United States)
Topics & keywords
- Medicine
- Prostate cancer
- Cancer research
- Radiation therapy
- Cancer
- Myeloid-derived Suppressor Cell
- Myeloid
- Cytokine
- Good health and well-being