Association Between Use of Lung-Protective Ventilation With Lower Tidal Volumes and Clinical Outcomes Among Patients Without Acute Respiratory Distress Syndrome

ContextLung-protective mechanical ventilation with the use of lower tidal volumes has been found to improve outcomes of patients with acute respiratory distress syndrome (ARDS). It has been suggested that use of lower tidal volumes also benefits patients who do not have ARDS.ObjectiveTo determine whether use of lower tidal volumes is associated with improved outcomes of patients receiving ventilation who do not have ARDS.Data SourcesMEDLINE, CINAHL, Web of Science, and Cochrane Central Register of Controlled Trials up to August 2012.Study SelectionEligible studies evaluated use of lower vs higher tidal volumes in patients without ARDS at onset of mechanical ventilation and reported lung injury development,…