Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
Martin University · Ospedale Policlinico San Martino · +1 more institution
Abstract
We studied the immunoregulatory features of murine mesenchymal stem cells (MSCs) in vitro and in vivo. MSCs inhibited T-cell receptor (TCR)-dependent and -independent proliferation but did not induce apoptosis on T cells. Such inhibition was paired with a decreased interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha production and was partially reversed by interleukin-2 (IL-2). Thus, we used MSCs to treat myelin oligodendrocyte glycoprotein (MOG)35-55-induced experimental autoimmune encephalomyelitis (EAE) in C57BL/6J mice. We injected intravenously 1 x 10(6) MSCs before disease onset (preventive protocol) and at different time points after disease occurrence (therapeutic protocol). MSC administration…
Citation impact
- FWCI
- 30.74
- Percentile
- 100%
- References
- 31
Authors
12- EZEmanuela ZappiaCorresponding
Martin University, Ospedale Policlinico San Martino, University of Genoa
- SCSimona Casazza
Martin University, Ospedale Policlinico San Martino, University of Genoa
- EPEnrico Pedemonte
Martin University, Ospedale Policlinico San Martino, University of Genoa
- FBFederica Benvenuto
Martin University, Ospedale Policlinico San Martino, University of Genoa
- IBIvan Bonanni
Martin University, Ospedale Policlinico San Martino, University of Genoa
Topics & keywords
- Experimental autoimmune encephalomyelitis
- Mesenchymal stem cell
- Immunology
- Myelin oligodendrocyte glycoprotein
- Encephalomyelitis
- Autoimmune disease
- Medicine
- T cell
- Good health and well-being