reviewHypertensionApr 22, 2003BRONZE OA

Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease?

RJRichard J. JohnsonDKDuk‐Hee KangDIDaniel I. FeigSDSalah D. KivlighnJKJohn Kanellis

Providence Sacred Heart Medical Center · United States Military Academy · +3 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In this report, we review the epidemiologic evidence and potential mechanisms for this association. We also summarize experimental studies that demonstrate that uric acid is not inert but may have both beneficial functions (acting as an antioxidant) as well as detrimental actions (to stimulate vascular smooth muscle cell proliferation and induce endothelial dysfunction). A recently developed experimental model of mild hyperuricemia also provides the first provocative evidence that uric acid may have a pathogenic role in the development of hypertension, vascular disease, and renal disease. Thus, it is time…

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1,364
total citations
FWCI
22.39
Percentile
100%
References
108
Citations per year

Authors

10

Topics & keywords

Topics
Keywords
  • Hyperuricemia
  • Uric acid
  • Medicine
  • Disease
  • Vascular disease
  • Endothelial dysfunction
  • Kidney disease
  • Internal medicine
UN Sustainable Development Goals
  • Good health and well-being
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