Mice lacking ghrelin receptors resist the development of diet-induced obesity

Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHSR; ghrelin receptor). Since its discovery, accumulating evidence has suggested that ghrelin may play a role in signaling and reversing states of energy insufficiency. For example, ghrelin levels rise following food deprivation, and ghrelin administration stimulates feeding and increases body weight and adiposity. However, recent loss-of-function studies have raised questions regarding the physiological significance of ghrelin in regulating these processes. Here, we present results of a study using a novel GHSR-null mouse model, in which ghrelin administration fails to acutely stimulate food intake or activate arcuate nucleus…

• BI
  Beth Israel Deaconess Medical Center
• UO
  University of Cincinnati
• EF
  Endocrine Fellows Foundation
• NI
  National Institutes of Health

  Awards: DK57521, DK53301, P30 DK57521, DK59630
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Awards: NIDDK P30 DK57521, DK59630, P30 DK57521