Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy
National Cerebral and Cardiovascular Center · Kansai Rosai Hospital · +2 more institutions
Abstract
BACKGROUND: Pluripotent mesenchymal stem cells (MSCs) differentiate into a variety of cells, including cardiomyocytes and vascular endothelial cells. However, little information is available about the therapeutic potency of MSC transplantation in cases of dilated cardiomyopathy (DCM), an important cause of heart failure. METHODS AND RESULTS: We investigated whether transplanted MSCs induce myogenesis and angiogenesis and improve cardiac function in a rat model of DCM. MSCs were isolated from bone marrow aspirates of isogenic adult rats and expanded ex vivo. Cultured MSCs secreted large amounts of the angiogenic, antiapoptotic, and mitogenic factors vascular endothelial growth factor, hepatocyte growth factor,…
Citation impact
- FWCI
- 18.68
- Percentile
- 100%
- References
- 44
Authors
14- NNNoritoshi NagayaCorresponding
National Cerebral and Cardiovascular Center, Kansai Rosai Hospital, Tissue Dynamics (Israel), National Institute of Advanced Industrial Science and Technology
- KKKenji Kangawa
National Cerebral and Cardiovascular Center, Kansai Rosai Hospital, Tissue Dynamics (Israel), National Institute of Advanced Industrial Science and Technology
- TITakefumi Itoh
National Cerebral and Cardiovascular Center, Kansai Rosai Hospital, Tissue Dynamics (Israel), National Institute of Advanced Industrial Science and Technology
- TITakashi Iwase
National Cerebral and Cardiovascular Center, Kansai Rosai Hospital, Tissue Dynamics (Israel), National Institute of Advanced Industrial Science and Technology
- SMShinsuke Murakami
National Cerebral and Cardiovascular Center, Kansai Rosai Hospital, Tissue Dynamics (Israel), National Institute of Advanced Industrial Science and Technology
Topics & keywords
- Medicine
- Mesenchymal stem cell
- Transplantation
- Angiogenesis
- Cardiac function curve
- Hepatocyte growth factor
- Vascular endothelial growth factor
- Dilated cardiomyopathy
- Good health and well-being