Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer

Vergote, Ignace; Tropé, Claes G.; Amant, Frédéric; Kristensen, Gunnar B.; Ehlen, Tom; Johnson, Nick; Verheijen, René H.M.; Burg, Maria E.L. van der; Lacave, Ángel J.; Panici, Pierluigi Benedetti; Kenter, Gemma G.; Casado, Antonio; Mendiola, César; Coens, Corneel; Verleye, Leen; Stuart, Gavin; Pecorelli, Sërgio; Reed, N.S.

doi:10.1056/nejmoa0908806

articleNew England Journal of MedicineSep 1, 2010GREEN OA

Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer

IVIgnace Vergote CGClaes G. Tropé FAFrédéric Amant GBGunnar B. Kristensen TETom Ehlen

KU Leuven · Norwegian Cancer Society · +12 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Background

Primary debulking surgery before initiation of chemotherapy has been the standard of care for patients with advanced ovarian cancer.

Methods

We randomly assigned patients with stage IIIC or IV epithelial ovarian carcinoma, fallopian-tube carcinoma, or primary peritoneal carcinoma to primary debulking surgery followed by platinum-based chemotherapy or to neoadjuvant platinum-based chemotherapy followed by debulking surgery (so-called interval debulking surgery).

Citation impact

2,509

total citations

FWCI: 124.62
Percentile: 100%
References: 32

Citations per year

Authors

18

Topics & keywords

Topics

Keywords

Medicine
Ovarian cancer
Chemotherapy
Stage (stratigraphy)
Oncology
Internal medicine
Neoadjuvant therapy
Surgery

UN Sustainable Development Goals

Good health and well-being

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