Necrotic death as a cell fate
State University of New York · Cancer Research Institute · +3 more institutions
Abstract
Organismal homeostasis depends on an intricate balance between cell death and renewal. Early pathologists recognized that this balance could be disrupted by the extensive damage observed in internal organs during the course of certain diseases. This form of tissue damage was termed "necrosis", derived from the Greek "nekros" for corpse. As it became clear that the essential building block of tissue was the cell, necrosis came to be used to describe pathologic cell death. Until recently, necrotic cell death was believed to result from injuries that caused an irreversible bioenergetic compromise. The cell dying by necrosis has been viewed as a victim of extrinsic events beyond its control. However, recent…
Citation impact
- FWCI
- —
- Percentile
- —
- References
- 175
Authors
2- WZWei‐Xing ZongCorresponding
State University of New York, Cancer Research Institute, UPMC Hillman Cancer Center, Stony Brook University, University of Pennsylvania
- CBCraig B. Thompson
State University of New York, Cancer Research Institute, UPMC Hillman Cancer Center, Stony Brook University, University of Pennsylvania
Topics & keywords
- Biology
- Necrosis
- Programmed cell death
- Cell biology
- Cell
- Necroptosis
- Apoptosis
- Genetics
- Good health and well-being