Activity Patterns in a Model for the Subthalamopallidal Network of the Basal Ganglia

Based on recent experimental data, we have developed a conductance-based computational network model of the subthalamic nucleus and the external segment of the globus pallidus in the indirect pathway of the basal ganglia. Computer simulations and analysis of this model illuminate the roles of the coupling architecture of the network, and associated synaptic conductances, in modulating the activity patterns displayed by this network. Depending on the relationships of these coupling parameters, the network can support three general classes of sustained firing patterns: clustering, propagating waves, and repetitive spiking that may show little regularity or correlation. Each activity pattern can occur…

• NS
  National Science Foundation

  Awards: 9804447, 0103822
• NI
  National Institutes of Health

  Award: NS26473