The role of TGF-β signaling in myocardial infarction and cardiac remodeling
Baylor College of Medicine · Methodist Hospital
Abstract
Transforming Growth Factor (TGF)-beta is markedly induced and rapidly activated in the infarcted myocardium. However, understanding of the exact role of TGF-beta signaling in the infarcted and remodeling heart has been hampered by the complex and unusual biology of TGF-beta activation and by the diversity of its effects eliciting multiple, and often opposing cellular responses. Experimental studies suggest that TGF-beta signaling may be crucial for repression of inflammatory gene synthesis in healing infarcts mediating resolution of the inflammatory infiltrate. In addition, TGF-beta may play an important role in modulating fibroblast phenotype and gene expression, promoting extracellular matrix deposition in…
Citation impact
- FWCI
- 15.64
- Percentile
- 100%
- References
- 103
Authors
2Topics & keywords
- Extracellular matrix
- Transforming growth factor
- Fibrosis
- Ventricular remodeling
- Fibronectin
- Cardiac fibrosis
- Transforming growth factor beta
- Myofibroblast
- Good health and well-being