Phenotypic, Functional, and Plasticity Features of Classical and Alternatively Activated Human Macrophages
Royal Children's Hospital · Children's Medical Research Institute · +5 more institutions
Abstract
Macrophages are dynamic cells that mature under the influence of signals from the local microenvironment into either classically (M1) or alternatively (M2) activated macrophages with specific functional and phenotypic properties. Although the phenotypic identification of M1 and M2 macrophages is well established in mice, this is less clear for human macrophages. In addition, the persistence and reversibility of polarized human phenotypes is not well established. Human peripheral blood monocytes were differentiated into uncommitted macrophages (M0) and then polarized to M1 and M2 phenotypes using LPS/IFN-γ and IL-4/IL-13, respectively. M1 and M2 were identified as CD64(+)CD80(+) and CD11b(+)CD209(+),…
Citation impact
- FWCI
- 9.58
- Percentile
- 100%
- References
- 52
Authors
6- AAAbdullah A. TariqueCorresponding
Royal Children's Hospital, Children's Medical Research Institute, The University of Queensland, Queensland Children’s Medical Research Institute
- JLJayden Logan
Royal Children's Hospital, Children's Medical Research Institute, The University of Queensland, Queensland Children’s Medical Research Institute, Children's Health Queensland Hospital and Health Service
- ETEmma Thomas
Royal Children's Hospital, Children's Medical Research Institute, The University of Queensland, Queensland Children’s Medical Research Institute, Children's Health Queensland Hospital and Health Service
- PGPatrick G. Holt
Royal Children's Hospital, Children's Medical Research Institute, The University of Queensland, The Kids Research Institute Australia, The University of Western Australia, Queensland Children’s Medical Research Institute
- PDPeter D. Sly
Royal Children's Hospital, Children's Medical Research Institute, The University of Queensland, Queensland Children’s Medical Research Institute, Children's Health Queensland Hospital and Health Service
Topics & keywords
- Phenotype
- Phenotypic plasticity
- Plasticity
- Biology
- Cell biology
- Computational biology
- Genetics
- Gene