HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
New York Academy of Medicine · Johns Hopkins University · +3 more institutions
Abstract
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral…
Citation impact
- FWCI
- 20.53
- Percentile
- 100%
- References
- 23
Authors
18- SISalim I. KhakooCorresponding
New York Academy of Medicine, Johns Hopkins University, National Cancer Institute, University of Southampton, Science Applications International Corporation (United States)
- CLChloe L. Thio
New York Academy of Medicine, Johns Hopkins University, National Cancer Institute, University of Southampton, Science Applications International Corporation (United States)
- MPMaureen P. Martin
New York Academy of Medicine, Johns Hopkins University, National Cancer Institute, University of Southampton, Science Applications International Corporation (United States)
- CBCollin Brooks
New York Academy of Medicine, Johns Hopkins University, National Cancer Institute, University of Southampton, Science Applications International Corporation (United States)
- XGXiaojiang Gao
New York Academy of Medicine, Johns Hopkins University, National Cancer Institute, University of Southampton, Science Applications International Corporation (United States)
Topics & keywords
- Human leukocyte antigen
- Biology
- Hepatitis C virus
- Innate immune system
- Major histocompatibility complex
- Virus
- Immunology
- Virology
- Good health and well-being