articleKidney & Blood Pressure ResearchJan 1, 2013GOLD OA

Kruppel-Like Factor 15 Modulates Renal Interstitial Fibrosis by ERK/MAPK and JNK/MAPK Pathways Regulation

XGXiang GaoGWGuiqun WuXGXiangchen GuLFLili FuCMChanglin Mei

Second Military Medical University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor antagonists (AT1RA) slow the rate of progression of experimental renal disease. Although the end result of both classes of drugs is to block the renin-angiotensin system (RAS), ACEI and AT1RA act at different sites in the RAS cascade. The aim of this study was to compare the effects of an ACEI (enalapril) and AT1RA (losartan), alone or in combination, in slowing the progression of experimental renal disease in a model of reduced renal mass. Two weeks after 5/6 renal ablation, rats were divided into five groups matched for body weight, systolic BP (SBP), and urinary protein excretion rate (UprotV). The effects on SBP and UprotV of…

Citation impact

1,038
total citations
FWCI
34.85
Percentile
100%
References
51
Citations per year

Authors

5

Topics & keywords

Topics
Keywords
  • CTGF
  • MAPK/ERK pathway
  • Endocrinology
  • Extracellular matrix
  • Fibrosis
  • Growth factor
  • Internal medicine
  • Transforming growth factor
No related works found for this paper.

Funding