articleHuman GenomicsJan 1, 2008GOLD OA

Human ATP-binding cassette (ABC) transporter family

VVVasilis VasiliouKVKonstandinos VasiliouDWDaniel W. Nebert

University of Colorado Denver · University of Cincinnati Medical Center · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

There exist four fundamentally different classes of membrane-bound transport proteins: ion channels; transporters; aquaporins; and ATP-powered pumps. ATP-binding cassette (ABC) transporters are an example of ATP-dependent pumps. ABC transporters are ubiquitous membrane-bound proteins, present in all prokaryotes, as well as plants, fungi, yeast and animals. These pumps can move substrates in (influx) or out (efflux) of cells. In mammals, ABC transporters are expressed predominantly in the liver, intestine, blood-brain barrier, blood-testis barrier, placenta and kidney. ABC proteins transport a number of endogenous substrates, including inorganic anions, metal ions, peptides, amino acids, sugars and a large…

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Topics & keywords

Topics
Keywords
  • ATP-binding cassette transporter
  • Biology
  • Efflux
  • Transporter
  • Antiporter
  • Membrane transport protein
  • Membrane protein
  • Biochemistry
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