Identification of Targetable FGFR Gene Fusions in Diverse Cancers
Howard Hughes Medical Institute · National Health Research Institutes · +5 more institutions
Abstract
Abstract Through a prospective clinical sequencing program for advanced cancers, four index cases were identified which harbor gene rearrangements of FGFR2, including patients with cholangiocarcinoma, breast cancer, and prostate cancer. After extending our assessment of FGFR rearrangements across multiple tumor cohorts, we identified additional FGFR fusions with intact kinase domains in lung squamous cell cancer, bladder cancer, thyroid cancer, oral cancer, glioblastoma, and head and neck squamous cell cancer. All FGFR fusion partners tested exhibit oligomerization capability, suggesting a shared mode of kinase activation. Overexpression of FGFR fusion proteins induced cell proliferation. Two bladder cancer…
Citation impact
- FWCI
- 30.51
- Percentile
- 100%
- References
- 47
Authors
25- YWYi-Mi Wu
Howard Hughes Medical Institute, National Health Research Institutes, University of Michigan, Michigan Center for Translational Pathology, Comprehensive Blood & Cancer Center, U-M Rogel Cancer Center
- FSFengyun Su
Howard Hughes Medical Institute, National Health Research Institutes, University of Michigan, Michigan Center for Translational Pathology, Comprehensive Blood & Cancer Center, U-M Rogel Cancer Center
- SKShanker Kalyana‐Sundaram
Howard Hughes Medical Institute, National Health Research Institutes, University of Michigan, Michigan Center for Translational Pathology, Comprehensive Blood & Cancer Center, U-M Rogel Cancer Center
- NANickolay A. Khazanov
Howard Hughes Medical Institute, National Health Research Institutes, Chang Gung University, University of Michigan, Michigan Center for Translational Pathology, Comprehensive Blood & Cancer Center, U-M Rogel Cancer Center
- BABushra Ateeq
Howard Hughes Medical Institute, National Health Research Institutes, University of Michigan, Michigan Center for Translational Pathology, Comprehensive Blood & Cancer Center, U-M Rogel Cancer Center
Topics & keywords
- Identification (biology)
- Gene
- Computational biology
- Biology
- Cancer
- Fibroblast growth factor receptor
- Cancer research
- Genetics
- Good health and well-being