SuperTarget and Matador: resources for exploring drug-target relationships
Institute of Bioinformatics · Heidelberg University · +5 more institutions
Abstract
The molecular basis of drug action is often not well understood. This is partly because the very abundant and diverse information generated in the past decades on drugs is hidden in millions of medical articles or textbooks. Therefore, we developed a one-stop data warehouse, SuperTarget that integrates drug-related information about medical indication areas, adverse drug effects, drug metabolization, pathways and Gene Ontology terms of the target proteins. An easy-to-use query interface enables the user to pose complex queries, for example to find drugs that target a certain pathway, interacting drugs that are metabolized by the same cytochrome P450 or drugs that target the same protein but are metabolized by…
Citation impact
- FWCI
- 16.08
- Percentile
- 100%
- References
- 18
Authors
16- SGStefan GüntherCorresponding
Institute of Bioinformatics
- MKMichael Kuhn
Heidelberg University, Max Delbrück Center, University Hospital Heidelberg, University of Montana, Charité - Universitätsmedizin Berlin, Institute of Molecular Biology
- MDMathias Dunkel
Heidelberg University, University Hospital Heidelberg, Charité - Universitätsmedizin Berlin, Max Delbrück Center, Institute of Molecular Biology, University of Montana
- MCMónica Campillos
Charité - Universitätsmedizin Berlin, University Hospital Heidelberg, Heidelberg University, University of Montana, Institute of Molecular Biology, Max Delbrück Center
- CSChristian Senger
Institute of Molecular Biology, Charité - Universitätsmedizin Berlin, University of Montana, Heidelberg University, University Hospital Heidelberg, Max Delbrück Center
Topics & keywords
- Biology
- Drug
- Computational biology
- Genetics
- Evolutionary biology
- Pharmacology