articlePLoS ONEJun 27, 2013GOLD OA

BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer’s Disease

CGChristian GaserKFKatja FrankeSKStefan KlöppelNKNikolaos KoutsoulerisHSHeinrich Sauer

Jena University Hospital · University Medical Center Freiburg · +1 more institution

PubMed
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Abstract

Alzheimer's disease (AD), the most common form of dementia, shares many aspects of abnormal brain aging. We present a novel magnetic resonance imaging (MRI)-based biomarker that predicts the individual progression of mild cognitive impairment (MCI) to AD on the basis of pathological brain aging patterns. By employing kernel regression methods, the expression of normal brain-aging patterns forms the basis to estimate the brain age of a given new subject. If the estimated age is higher than the chronological age, a positive brain age gap estimation (BrainAGE) score indicates accelerated atrophy and is considered a risk factor for conversion to AD. Here, the BrainAGE framework was applied to predict the…

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Topics & keywords

Topics
Keywords
  • Alzheimer's disease
  • Disease
  • Cognition
  • Medicine
  • Dementia
  • Internal medicine
  • Psychiatry
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