Rfam 12.0: updates to the RNA families database
Janelia Research Campus · European Bioinformatics Institute · +2 more institutions
Abstract
The Rfam database (available at http://rfam.xfam.org) is a collection of non-coding RNA families represented by manually curated sequence alignments, consensus secondary structures and annotation gathered from corresponding Wikipedia, taxonomy and ontology resources. In this article, we detail updates and improvements to the Rfam data and website for the Rfam 12.0 release. We describe the upgrade of our search pipeline to use Infernal 1.1 and demonstrate its improved homology detection ability by comparison with the previous version. The new pipeline is easier for users to apply to their own data sets, and we illustrate its ability to annotate RNAs in genomic and metagenomic data sets of various sizes. Rfam…
Citation impact
- FWCI
- 50.79
- Percentile
- 100%
- References
- 39
Authors
11- EPEric P. NawrockiCorresponding
Janelia Research Campus
- SBSarah Burge
European Bioinformatics Institute, Wellcome Trust
- ABAlex Bateman
European Bioinformatics Institute, Wellcome Trust
- JDJennifer Daub
European Bioinformatics Institute, Wellcome Trust
- RYRuth Y. Eberhardt
European Bioinformatics Institute, Wellcome Trust
Topics & keywords
- Pipeline (software)
- Computational biology
- Biology
- Computer science
- Metagenomics
- Ribosomal RNA
- Information retrieval
- Database