PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology Consortium
Lawrence Berkeley National Laboratory · Northwestern University · +1 more institution
Abstract
Protein Analysis THrough Evolutionary Relationships (PANTHER) is a comprehensive software system for inferring the functions of genes based on their evolutionary relationships. Phylogenetic trees of gene families form the basis for PANTHER and these trees are annotated with ontology terms describing the evolution of gene function from ancestral to modern day genes. One of the main applications of PANTHER is in accurate prediction of the functions of uncharacterized genes, based on their evolutionary relationships to genes with functions known from experiment. The PANTHER website, freely available at http://www.pantherdb.org, also includes software tools for analyzing genomic data relative to known and inferred…
Citation impact
- FWCI
- 19.57
- Percentile
- 100%
- References
- 29
Authors
6- HMHuaiyu MiCorresponding
Lawrence Berkeley National Laboratory
- QDQing Dong
Northwestern University, SRI International, Lawrence Berkeley National Laboratory
- AMAnushya Muruganujan
Northwestern University, SRI International, Lawrence Berkeley National Laboratory
- PGPascale Gaudet
Northwestern University, SRI International, Lawrence Berkeley National Laboratory
- SLSuzanna Lewis
Northwestern University, SRI International, Lawrence Berkeley National Laboratory
Topics & keywords
- Biology
- Phylogenetic tree
- Genome
- Gene
- Computational biology
- Phylogenetics
- Function (biology)
- Gene nomenclature